Antibody humanization by structure-based computational protein design
نویسندگان
چکیده
منابع مشابه
Antibody Humanization Techniques
Antibodies are proteins with very important functions in the immune system. Thanks to their ability to recognize specific sequences from pathogens and other threats, antibodies can participate in the recognition and removal of foreign threats, such as virus and bacteria (Janeway et al.). Every human body is able to create millions of slightly different antibodies; every antibody has the ability...
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Most forms of chronic pain are inadequately treated by present therapeutic options. Compelling evidence has accumulated, demonstrating that Nerve Growth Factor (NGF) is a key modulator of inflammatory and nociceptive responses, and is a promising target for the treatment of human pathologies linked to chronic and inflammatory pain. There is therefore a growing interest in the development of the...
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Structure-based computational methods continue to enhance progress in the discovery and refinement of therapeutic agents. Several such methods and their applications are described. These include molecular visualization and molecular modeling, docking, fragment methods, 3-D database techniques, and free-energy perturbation. Related issues that are discussed include the use of simplified potentia...
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ژورنال
عنوان ژورنال: mAbs
سال: 2015
ISSN: 1942-0862,1942-0870
DOI: 10.1080/19420862.2015.1076600